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More info:
Retrovir: Foundational HIV Treatment and Prevention - Evidence-Based Review
Zidovudine, marketed under the brand name Retrovir, represents the foundational antiretroviral agent in the global fight against Human Immunodeficiency Virus (HIV). As the first medication approved by the FDA specifically for HIV treatment back in 1987, it fundamentally shifted the paradigm from a fatal diagnosis to a manageable chronic condition. This nucleoside reverse transcriptase inhibitor (NRTI) works by incorporating itself into the viral DNA chain during replication, causing premature termination and halting the virus’s ability to multiply.
Sustiva: Effective HIV-1 Management Through Targeted Antiretroviral Action - Evidence-Based Review
Sustiva is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination antiretroviral therapy for HIV-1 infection. The medication, known generically as efavirenz, represents one of the cornerstone agents in modern HIV management since its approval in the late 1990s. What makes Sustiva particularly noteworthy isn’t just its potent antiviral activity but its unique pharmacokinetic profile that enables once-daily dosing—a significant advantage in a field where medication adherence directly correlates with treatment success and resistance prevention.
Zerit: Effective Antiretroviral Therapy for HIV Management - Evidence-Based Review
Stavudine, marketed under the brand name Zerit, is a nucleoside reverse transcriptase inhibitor (NRTI) that has played a significant role in antiretroviral therapy, particularly in the management of HIV-1 infection. As a synthetic thymidine nucleoside analogue, it requires intracellular phosphorylation to its active triphosphate form, which then competes with natural thymidine triphosphate for incorporation into viral DNA by reverse transcriptase. This incorporation terminates the growing DNA chain due to the absence of a 3’-hydroxyl group, thereby inhibiting viral replication.
biaxin
Biaxin, known generically as clarithromycin, is a macrolide antibiotic with a distinctive 14-membered lactone ring structure that’s been modified from erythromycin to enhance acid stability and tissue penetration. What’s fascinating clinically isn’t just its broad-spectrum coverage against respiratory pathogens, but how its unique metabolite, 14-hydroxy-clarithromycin, creates this synergistic antibacterial effect that’s particularly valuable in stubborn bronchitis cases. Key Components and Bioavailability of Biaxin The molecular structure contains a methoxy group at the 6-position - that’s the key modification that reduces acid degradation in the stomach compared to erythromycin.
biktarvy
Biktarvy represents one of those rare clinical advances where the simplification of HIV treatment actually translated to better outcomes across diverse patient populations. As a complete single-tablet regimen containing bictegravir 50mg, emtricitabine 200mg, and tenofovir alafenamide 25mg, this medication has fundamentally changed how we approach antiretroviral therapy in both treatment-naïve and treatment-experienced patients. 1. Introduction: What is Biktarvy? Its Role in Modern HIV Management Biktarvy stands as a landmark in HIV therapeutics - a once-daily single tablet regimen that combines an integrase strand transfer inhibitor with two nucleoside reverse transcriptase inhibitors.
epivir hbv
Epivir HBV is the brand name for lamivudine, an oral nucleoside analogue antiviral medication specifically formulated for the treatment of chronic hepatitis B virus (HBV) infection. It is not a dietary supplement or a medical device, but a prescription pharmaceutical that inhibits viral replication by targeting the HBV polymerase enzyme. Its role in modern hepatology has evolved significantly since its initial development, particularly as a foundational agent in managing HBV-related liver complications, though its use today is often guided by resistance profiles and newer therapeutic options.
hydrea
Hydroxyurea, commonly known by its brand name Hydrea, represents one of those foundational chemotherapeutic agents that’s been around for decades yet remains remarkably relevant in modern hematology practice. It’s an oral antimetabolite that essentially tricks rapidly dividing cells into incorporating a faulty version of DNA building blocks, causing them to self-destruct. What’s fascinating is how this simple mechanism has found applications across such a wide spectrum of blood disorders - from sickle cell disease to certain leukemias.
indinavir
Indinavir sulfate is a protease inhibitor antiretroviral medication used primarily in the treatment of HIV-1 infection. It belongs to the class of drugs that specifically target the HIV protease enzyme, preventing viral replication in infected cells. Available in 400 mg capsule form, this pharmaceutical requires careful dosing considerations due to its pharmacokinetic profile and potential interactions. 1. Introduction: What is Indinavir? Its Role in Modern Medicine Indinavir (brand name Crixivan) represents a significant advancement in antiretroviral therapy, having received FDA approval in 1996 during the critical period of developing effective HIV treatments.
kaletra
Kaletra represents one of the most significant advances in HIV treatment over the past two decades. As a fixed-dose combination of lopinavir and ritonavir, this antiretroviral medication fundamentally changed how we manage HIV-1 infection when it was first introduced. I still remember the excitement in our infectious disease department when we got our first samples—we knew this wasn’t just another protease inhibitor, but something that could genuinely transform patient outcomes.
