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Synonyms | |||
More info:
amitriptyline
Amitriptyline is a tricyclic antidepressant (TCA) that’s been in clinical use since the 1960s, primarily indicated for major depressive disorder but possessing a remarkably broad therapeutic profile that extends far beyond its original designation. What’s fascinating is how this older medication has maintained relevance through decades of pharmaceutical innovation, largely due to its multifaceted mechanism and cost-effectiveness. Unlike many newer antidepressants that target specific neurotransmitter systems with precision, amitriptyline exerts effects across multiple pathways, which explains both its efficacy and its side effect profile.
alphagan
Brimonidine tartrate ophthalmic solution 0.15% - that’s what we’re really talking about when we say Alphagan. It’s not some new miracle drug, but rather a well-established alpha-2 adrenergic agonist that’s been around since the late 1990s. I remember when it first hit the market, we were all excited about having another option beyond beta-blockers for our glaucoma patients. The 0.15% formulation came later, offering similar efficacy with potentially fewer side effects.
asendin
Amoxapine, marketed under the brand name Asendin, represents a unique tricyclic antidepressant (TCA) with a complex pharmacological profile that sets it apart from its predecessors. It’s the N-desmethyl derivative of the antipsychotic loxapine, giving it both antidepressant and mild antipsychotic properties—a dual mechanism we rarely see in this class. When I first encountered it during my psychopharmacology rotation in the late 90s, the attending physician called it “the thinking man’s TCA” because of its nuanced receptor binding.
Desyrel: Multifunctional Therapeutic Agent for Depression and Sleep Disorders - Evidence-Based Review
Trazodone hydrochloride, marketed under the brand name Desyrel among others, represents one of those fascinating compounds that defied initial expectations. When I first encountered it during my residency in the late 80s, we primarily used it as a second-line antidepressant, but over the decades, its profile has evolved significantly. What started as a serotonin antagonist and reuptake inhibitor (SARI) has become one of our most versatile psychotropic tools, particularly for addressing the complex interplay between depression, anxiety, and sleep disturbances.
Effexor XR: Effective Dual Reuptake Inhibition for Mood and Anxiety Disorders - Evidence-Based Review
Effexor XR, known generically as venlafaxine hydrochloride, is an extended-release antidepressant belonging to the serotonin-norepinephrine reuptake inhibitor (SNRI) class. It’s widely prescribed for major depressive disorder, generalized anxiety disorder, social anxiety disorder, and panic disorder. The “XR” formulation allows for once-daily dosing, which improves adherence and provides steady-state plasma concentrations, a significant advancement over the original immediate-release version. 1. Introduction: What is Effexor XR? Its Role in Modern Medicine Effexor XR (venlafaxine HCl extended-release) represents a cornerstone in contemporary psychopharmacology.
elavil
Amitriptyline, known by its brand name Elavil, is a tricyclic antidepressant (TCA) with a complex pharmacologic profile that extends far beyond its original psychiatric indications. Initially approved by the FDA in the early 1960s for major depressive disorder, its utility has expanded significantly in neurology, pain management, and even gastroenterology due to its multifaceted mechanism of action. It’s one of those foundational drugs that every clinician should understand deeply, not just for its benefits but for its nuanced risk profile.
endep
Endep is a tricyclic antidepressant medication primarily containing amitriptyline hydrochloride. It’s been a cornerstone in psychiatric and pain management for decades, originally developed as an antidepressant but now more commonly prescribed for chronic pain conditions like neuropathic pain and migraine prevention. What’s fascinating about Endep is how its mechanism—primarily norepinephrine and serotonin reuptake inhibition—translates into such diverse therapeutic applications. I’ve been prescribing it since my residency in the late 90s, and it remains one of those workhorse drugs that every seasoned clinician keeps in their toolkit.
flexeril
Cyclobenzaprine is a centrally-acting muscle relaxant that’s been in clinical use for decades, yet remains widely misunderstood in its mechanisms and appropriate applications. When I first encountered this medication during my residency, the attending physician described it as “a sedative that happens to relax muscles” - an oversimplification that stuck with me through years of clinical practice. The reality, as I’ve come to understand through treating hundreds of patients and reviewing the literature, is far more nuanced.
Fluoxetine: Sustained Serotonin Modulation for Depression and Anxiety - Evidence-Based Review
Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) antidepressant that has fundamentally changed how we approach mood and anxiety disorders since its introduction. As a clinician who’s prescribed it for over two decades, I’ve seen firsthand how this molecule can rewrite life stories—but only when used correctly. The journey from chemical compound to clinical tool is far more nuanced than the pharmacology textbooks suggest. 1. Introduction: What is Fluoxetine? Its Role in Modern Medicine When we talk about fluoxetine in clinical practice, we’re discussing one of the most studied psychotropic medications in history.